Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1

The ufmylation ligase-UFL1 promotes ATM activation by monoufmylating H4 at K31 in a positive-feedback loop after double-strand breaks (DSB) occur, whereas UFM1 Specific Peptidase 2 (UfSP2) suppresses ATM activation, but the mechanism of recruitment of UfSP2 to the DSB finetuning DNA damage response...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Bo, Yu, Jia, Zhao, Fei, Huang, Jinzhou, Zhou, Qin, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418083/
https://www.ncbi.nlm.nih.gov/pubmed/36042814
http://dx.doi.org/10.1007/s42764-022-00076-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418083/
https://www.ncbi.nlm.nih.gov/pubmed/36042814
http://dx.doi.org/10.1007/s42764-022-00076-z

Ejemplares similares