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Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1
The ufmylation ligase-UFL1 promotes ATM activation by monoufmylating H4 at K31 in a positive-feedback loop after double-strand breaks (DSB) occur, whereas UFM1 Specific Peptidase 2 (UfSP2) suppresses ATM activation, but the mechanism of recruitment of UfSP2 to the DSB finetuning DNA damage response...
Autores principales: | Qin, Bo, Yu, Jia, Zhao, Fei, Huang, Jinzhou, Zhou, Qin, Lou, Zhenkun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418083/ https://www.ncbi.nlm.nih.gov/pubmed/36042814 http://dx.doi.org/10.1007/s42764-022-00076-z |
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