Cargando…

MiR-6511b-5p suppresses metastasis of pMMR colorectal cancer through methylation of CD44 by directly targeting BRG1

PURPOSE: Distal metastases are a major cause of poor prognosis in colorectal cancer patients. Approximately 95% of metastatic colorectal cancers are defined as DNA mismatch repair proficient (pMMR). Our previous study found that miR-6511b-5p was downregulated in pMMR colorectal cancer. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, JinMing, Ye, Ling, Shi, Yuan, Wang, XingWei, Zhao, XiaFei, Ren, ShengYong, Fan, JunWei, Shao, HuanZhang, Qin, BingYu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418090/ https://www.ncbi.nlm.nih.gov/pubmed/35590122 http://dx.doi.org/10.1007/s12094-022-02845-4

Ejemplares similares

Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough Challenge
por: Marmorino, Federica, et al.
Publicado: (2020)

Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer
por: Lin, Haishan, et al.
Publicado: (2022)

Case report: Bullous pemphigoid associated with sintilimab therapy for pMMR/MSS colorectal cancer
por: Wang, Ting, et al.
Publicado: (2023)

Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4(+) T Cells in the Central Region of pMMR CRC
por: Qi, Jingwen, et al.
Publicado: (2021)

Gene Expression Profile Reveals a Prognostic Signature of Non–MSI-H/pMMR Colorectal Cancer
por: Liu, Zaoqu, et al.
Publicado: (2022)

Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria
por: Sun, Ci-Yuan, et al.
Publicado: (2020)

A Case of Complete Remission in Proficient Mismatch Repair (pMMR) Advanced Colon Cancer Treated with Sintilimab and XELOX
por: Zhu, Jiangpeng, et al.
Publicado: (2023)

PD-1 inhibitor combined with radiotherapy and GM-CSF in MSS/pMMR metastatic colon cancer: a case report
por: Yang, Jiabao, et al.
Publicado: (2023)

Recurrent Gallbladder Carcinoma With pMMR/MSS Achieved a Complete Response Following Camrelizumab Combined With Apatinib: A Case Report
por: Zhong, Liting, et al.
Publicado: (2022)

Immunotherapy combined with local therapy in the late-line treatment of repair-proficient (pMMR)/microsatellite stable (MSS) metastatic colorectal cancer
por: Ding, Yuwei, et al.
Publicado: (2023)

Fruquintinib in Combination With PD-1 Inhibitors in Patients With Refractory Non-MSI-H/pMMR Metastatic Colorectal Cancer: A Real-World Study in China
por: Gou, Miaomiao, et al.
Publicado: (2022)

Squamous cell carcinoma of ascending colon with pMMR/MSS showed a partial response to PD-1 blockade combined with chemotherapy: A case report
por: Liu, Yan, et al.
Publicado: (2023)

Rectosigmoid-Junction Squamous Cell Carcinoma With pMMR/MSS Achieved a Partial Response Following PD-1 Blockade Combined With Chemotherapy: A Case Report
por: He, Yanxin, et al.
Publicado: (2021)

Successful Treatment of pMMR MSS IVB Colorectal Cancer Using Anti-VEGF and Anti-PD-1 Therapy in Combination of Gut Microbiota Transplantation: A Case Report
por: Cheng, Xianshuo, et al.
Publicado: (2023)

Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy of SBRT with PD-1 blockade
por: Liu, Xiaoliang, et al.
Publicado: (2019)

Treatment patterns and real-world clinical outcomes in patients with advanced endometrial cancer that are non-microsatellite instability high (non-MSI-high) or mismatch repair proficient (pMMR) in the United States
por: Kelkar, Sneha S., et al.
Publicado: (2022)

Mechanism of LncHOTAIR Regulating Proliferation, Apoptosis, and Autophagy of Lymphoma Cells through hsa-miR-6511b-5p/ATG7 Axis
por: Gui, Fu, et al.
Publicado: (2022)

Retracted: Mechanism of LncHOTAIR Regulating Proliferation, Apoptosis, and Autophagy of Lymphoma Cells through hsa-miR-6511b-5p/ATG7 Axis
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Efficacy and safety of immune checkpoint inhibitors in Proficient Mismatch Repair (pMMR)/ Non-Microsatellite Instability-High (non-MSI-H) metastatic colorectal cancer: a study based on 39 cohorts incorporating 1723 patients
por: Wu, Qing, et al.
Publicado: (2023)

BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo
por: Marquez-Vilendrer, Stefanie B., et al.
Publicado: (2016)

RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells
por: Yan, Xiaodong, et al.
Publicado: (2020)

Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
por: Wang, Guihua, et al.
Publicado: (2017)

SCF(FBW7)-mediated degradation of Brg1 suppresses gastric cancer metastasis
por: Huang, Li-Yu, et al.
Publicado: (2018)

Correction: Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
por: Wang, Guihua, et al.
Publicado: (2021)

The BRG1 transcriptional coregulator
por: Trotter, Kevin W., et al.
Publicado: (2008)

BRG1: Promoter or Suppressor of Cancer? The Outcome of BRG1’s Interaction with Specific Cellular Pathways
por: Shaykevich, Aaron, et al.
Publicado: (2023)

Brg1 regulates murine liver regeneration by targeting miR‐187‐5p dependent on Hippo signalling pathway
por: Gong, Junhua, et al.
Publicado: (2020)

Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b
por: Zhou, Zheng, et al.
Publicado: (2015)

A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis
por: Yang, Libang, et al.
Publicado: (2021)

Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis
por: Shi, Jinfeng, et al.
Publicado: (2021)

Robotically assisted peritoneal mesometrial resection (PMMR) in endometrial cancer supported by ICG labeling of the compartmental lymphatic system
por: Kimmig, Rainer, et al.
Publicado: (2016)

Improving health literacy with mumps, measles and rubella (MMR) vaccination: comparison of the readability of MMR patient-facing literature and MMR scientific abstracts
por: Downey, Tina, et al.
Publicado: (2022)

58-kDa Microspherule Protein (MSP58) Is Novel Brahma-related Gene 1 (BRG1)-associated Protein That Modulates p53/p21 Senescence Pathway
por: Hsu, Che-Chia, et al.
Publicado: (2012)

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44
por: Zou, Peng, et al.
Publicado: (2019)

circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p
por: Ye, Ling, et al.
Publicado: (2023)

Mechanism of BRG1 silencing in primary cancers
por: Marquez, Stefanie B., et al.
Publicado: (2016)

The Role of BRG1 in Antioxidant and Redox Signaling
por: You, Shilong, et al.
Publicado: (2020)

Oncogene-dependent function of BRG1 in hepatocarcinogenesis
por: Wang, Pan, et al.
Publicado: (2020)

On the Interaction Between SMARCAL1 and BRG1
por: Bisht, Deepa, et al.
Publicado: (2022)

Abscopal effect triggered by radiation sequential mono-immunotherapy resulted in a complete remission of PMMR sigmoid colon cancer
por: Zhou, Pu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_drb2daf3pcbbreig736cmc6fgv