Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in patients with S. aureus osteomyelitis is unknown. To address this knowledge gap, we completed a clinical study and observed elevated serum IL-27 levels (20-fold higher, P < 0...

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Detalles Bibliográficos
Autores principales: Morita, Yugo, Saito, Motoo, Rangel-Moreno, Javier, Franchini, Anthony M., Owen, John R., Martinez, John C., Daiss, John L., de Mesy Bentley, Karen L., Kates, Stephen L., Schwarz, Edward M., Muthukrishnan, Gowrishankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418173/
https://www.ncbi.nlm.nih.gov/pubmed/36028492
http://dx.doi.org/10.1038/s41413-022-00228-7

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