UDP-glucose, cereblon-dependent proinsulin degrader

Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon, and uridine binds and competes for proinsulin degradation and behaves as sustainable insulin secretagogue. U...

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Detalles Bibliográficos
Autores principales: Cho, Jaeyong, Miyagawa, Atsushi, Yamaguchi, Kazuki, Abe, Wakana, Tsugawa, Yoji, Yamamura, Hatsuo, Imai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418190/
https://www.ncbi.nlm.nih.gov/pubmed/36028536
http://dx.doi.org/10.1038/s41598-022-18902-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418190/
https://www.ncbi.nlm.nih.gov/pubmed/36028536
http://dx.doi.org/10.1038/s41598-022-18902-5

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