MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

α-ketoglutarate (αKG) is a central metabolic node with a broad influence on cellular physiology. The αKG analogue N-oxalylglycine (NOG) and its membrane-permeable pro-drug derivative dimethyl-oxalylglycine (DMOG) have been extensively used as tools to study prolyl hydroxylases (PHDs) and other αKG-d...

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Detalles Bibliográficos
Autores principales: Fets, Louise, Bevan, Natalie, Nunes, Patrícia M., Campos, Sebastien, dos Santos, Mariana Silva, Sherriff, Emma, MacRae, James I., House, David, Anastasiou, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418262/
https://www.ncbi.nlm.nih.gov/pubmed/36028752
http://dx.doi.org/10.1038/s42003-022-03805-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418262/
https://www.ncbi.nlm.nih.gov/pubmed/36028752
http://dx.doi.org/10.1038/s42003-022-03805-y

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