Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation

Normal hemostatic function is important for reduction of the risk of intracranial hemorrhage during stereotactic neurosurgery including deep brain stimulation (DBS) surgery. This study investigates the hemostatic function in patients with Parkinson’s disease (PD) undergoing preoperative evaluation f...

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Autores principales: Chou, Sheng-Che, Tai, Chun-Hwei, Tseng, Sheng-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418315/
https://www.ncbi.nlm.nih.gov/pubmed/36028530
http://dx.doi.org/10.1038/s41598-022-18992-1
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author Chou, Sheng-Che
Tai, Chun-Hwei
Tseng, Sheng-Hong
author_facet Chou, Sheng-Che
Tai, Chun-Hwei
Tseng, Sheng-Hong
author_sort Chou, Sheng-Che
collection PubMed
description Normal hemostatic function is important for reduction of the risk of intracranial hemorrhage during stereotactic neurosurgery including deep brain stimulation (DBS) surgery. This study investigates the hemostatic function in patients with Parkinson’s disease (PD) undergoing preoperative evaluation for DBS, with emphasis on the number and function of platelets. In 107 PD patients, only one had abnormal activated partial prothrombin time and normal prothrombin time. Among the other 106 patients, six (5.7%) had only thrombocytopenia, seven (6.6%) only prolonged bleeding time (BT), and 14 (13.2%) only prolonged closure time (CT) of platelet function analyzer 100 (PFA-100). Totally, 34 of the 106 patients (32.1%) had at least one of three kinds of platelet abnormalities. No factor was found to be associated with the occurrence of platelet abnormalities except that abnormal platelet group and prolonged BT subgroup had more patients using selegiline and lower UPDRS-III motor subscore with medication off than normal platelet group (p < 0.05). The use of selegiline was significantly correlated with prolonged BT (p = 0.0041) and platelet abnormality (p = 0.0197). Therefore, it is important to have detailed evaluation of the hemostatic function for PD patients undergoing preoperative evaluation for DBS, especially the platelet number and function.
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spelling pubmed-94183152022-08-28 Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation Chou, Sheng-Che Tai, Chun-Hwei Tseng, Sheng-Hong Sci Rep Article Normal hemostatic function is important for reduction of the risk of intracranial hemorrhage during stereotactic neurosurgery including deep brain stimulation (DBS) surgery. This study investigates the hemostatic function in patients with Parkinson’s disease (PD) undergoing preoperative evaluation for DBS, with emphasis on the number and function of platelets. In 107 PD patients, only one had abnormal activated partial prothrombin time and normal prothrombin time. Among the other 106 patients, six (5.7%) had only thrombocytopenia, seven (6.6%) only prolonged bleeding time (BT), and 14 (13.2%) only prolonged closure time (CT) of platelet function analyzer 100 (PFA-100). Totally, 34 of the 106 patients (32.1%) had at least one of three kinds of platelet abnormalities. No factor was found to be associated with the occurrence of platelet abnormalities except that abnormal platelet group and prolonged BT subgroup had more patients using selegiline and lower UPDRS-III motor subscore with medication off than normal platelet group (p < 0.05). The use of selegiline was significantly correlated with prolonged BT (p = 0.0041) and platelet abnormality (p = 0.0197). Therefore, it is important to have detailed evaluation of the hemostatic function for PD patients undergoing preoperative evaluation for DBS, especially the platelet number and function. Nature Publishing Group UK 2022-08-26 /pmc/articles/PMC9418315/ /pubmed/36028530 http://dx.doi.org/10.1038/s41598-022-18992-1 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chou, Sheng-Che
Tai, Chun-Hwei
Tseng, Sheng-Hong
Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title_full Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title_fullStr Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title_full_unstemmed Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title_short Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
title_sort platelet abnormalities in patients with parkinson's disease undergoing preoperative evaluation for deep brain stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418315/
https://www.ncbi.nlm.nih.gov/pubmed/36028530
http://dx.doi.org/10.1038/s41598-022-18992-1
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