Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

mTORC1 is hyperactive in multiple cancer types(1,2). Here, we performed integrative analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and spatial transcriptomic profiling on Tuberous Sclerosis Complex (TSC) associated tumors with mTORC1 hyperactivity, and ide...

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Detalles Bibliográficos
Autores principales: Tang, Yan, Kwiatkowski, David J., Henske, Elizabeth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418323/
https://www.ncbi.nlm.nih.gov/pubmed/36028490
http://dx.doi.org/10.1038/s41467-022-32673-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418323/
https://www.ncbi.nlm.nih.gov/pubmed/36028490
http://dx.doi.org/10.1038/s41467-022-32673-7

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