Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities

Hox proteins have similar binding specificities in vitro, yet they control different morphologies in vivo. This paradox has been partially solved with the identification of Hox low-affinity binding sites. However, anterior Hox proteins are more promiscuous than posterior Hox proteins, raising the qu...

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Detalles Bibliográficos
Autores principales: Pinto, Pedro B., Domsch, Katrin, Gao, Xuefan, Wölk, Michaela, Carnesecchi, Julie, Lohmann, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418327/
https://www.ncbi.nlm.nih.gov/pubmed/36028502
http://dx.doi.org/10.1038/s41467-022-32408-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418327/
https://www.ncbi.nlm.nih.gov/pubmed/36028502
http://dx.doi.org/10.1038/s41467-022-32408-8

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