Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism

Perforin-2 (PFN2, MPEG1) is a pore-forming protein that acts as a first line of defense in the mammalian immune system, rapidly killing engulfed microbes within the phagolysosome in macrophages. PFN2 self-assembles into hexadecameric pre-pore rings that transition upon acidification into pores damag...

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Detalles Bibliográficos
Autores principales: Jiao, Fang, Dehez, François, Ni, Tao, Yu, Xiulian, Dittman, Jeremy S., Gilbert, Robert, Chipot, Christophe, Scheuring, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418332/
https://www.ncbi.nlm.nih.gov/pubmed/36028507
http://dx.doi.org/10.1038/s41467-022-32757-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418332/
https://www.ncbi.nlm.nih.gov/pubmed/36028507
http://dx.doi.org/10.1038/s41467-022-32757-4

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