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A conserved domain of Drosophila RNA-binding protein Pumilio interacts with multiple CCR4–NOT deadenylase complex subunits to repress target mRNAs

Pumilio is a sequence-specific RNA-binding protein that controls development, stem cell fate, and neurological functions in Drosophila. Pumilio represses protein expression by destabilizing target mRNAs in a manner dependent on the CCR4–NOT deadenylase complex. Three unique repression domains in the...

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Detalles Bibliográficos
Autores principales:	Haugen, Rebecca J., Arvola, René M., Connacher, Robert P., Roden, Richard T., Goldstrohm, Aaron C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418443/ https://www.ncbi.nlm.nih.gov/pubmed/35850301 http://dx.doi.org/10.1016/j.jbc.2022.102270

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