G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias

G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-bound GPCRs to promote receptor desensitization and downregulation. They also trigger signaling cascades distinct from those of heterotrimeric G proteins. Biased agonists for GPCRs that favor either heterotrimeric G...

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Detalles Bibliográficos
Autores principales: Chen, Qiuyan, Tesmer, John J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418498/
https://www.ncbi.nlm.nih.gov/pubmed/35863432
http://dx.doi.org/10.1016/j.jbc.2022.102279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418498/
https://www.ncbi.nlm.nih.gov/pubmed/35863432
http://dx.doi.org/10.1016/j.jbc.2022.102279

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