ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesion

Rho GTP Exchange Factors (RhoGEFs) and Rho GTPase Activating Proteins (RhoGAPs) are large families of molecules that regulate shape determination in all eukaryotes. In pathologies such as melanoma, RhoGEF and RhoGAP activity underpins the ability of cells to invade tissues of varying elasticity. To...

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Detalles Bibliográficos
Autores principales: Bousgouni, Vicky, Inge, Oliver, Robertson, David, Jones, Ian, Clatworthy, Innes, Bakal, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418690/
https://www.ncbi.nlm.nih.gov/pubmed/36039362
http://dx.doi.org/10.1016/j.isci.2022.104795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418690/
https://www.ncbi.nlm.nih.gov/pubmed/36039362
http://dx.doi.org/10.1016/j.isci.2022.104795

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