Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation

Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering RNA (siRNA) (LNP-Lbp UNA-siRNA) on the development...

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Detalles Bibliográficos
Autores principales: Latorre, Jessica, Díaz-Trelles, Ramon, Comas, Ferran, Gavaldà-Navarro, Aleix, Milbank, Edward, Dragano, Nathalia, Morón-Ros, Samantha, Mukthavaram, Rajesh, Ortega, Francisco, Castells-Nobau, Anna, Oliveras-Cañellas, Núria, Ricart, Wifredo, Karmali, Priya P., Tachikawa, Kiyoshi, Chivukula, Pad, Villarroya, Francesc, López, Miguel, Giralt, Marta, Fernández-Real, José Manuel, Moreno-Navarrete, José María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418749/
https://www.ncbi.nlm.nih.gov/pubmed/36090751
http://dx.doi.org/10.1016/j.omtn.2022.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418749/
https://www.ncbi.nlm.nih.gov/pubmed/36090751
http://dx.doi.org/10.1016/j.omtn.2022.08.003

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