Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche

Most studies on leukemia focus on leukemia cells as isolated objects without considering the bone marrow niche. Pal et al. have recreated the bone marrow niche using induced pluripotent stem cells (iPSCs), identifying CDH2 as a therapeutically druggable leukemia-promoting factor.(1)

Detalles Bibliográficos
Autores principales: Borbaran-Bravo, Natalia, Arreba-Tutusaus, Patricia, Ritter, Malte U., Nasri, Masoud, Klimiankou, Maksim, Skokowa, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418842/
https://www.ncbi.nlm.nih.gov/pubmed/35977470
http://dx.doi.org/10.1016/j.xcrm.2022.100724
_version_ 1784777039582068736
author Borbaran-Bravo, Natalia
Arreba-Tutusaus, Patricia
Ritter, Malte U.
Nasri, Masoud
Klimiankou, Maksim
Skokowa, Julia
author_facet Borbaran-Bravo, Natalia
Arreba-Tutusaus, Patricia
Ritter, Malte U.
Nasri, Masoud
Klimiankou, Maksim
Skokowa, Julia
author_sort Borbaran-Bravo, Natalia
collection PubMed
description Most studies on leukemia focus on leukemia cells as isolated objects without considering the bone marrow niche. Pal et al. have recreated the bone marrow niche using induced pluripotent stem cells (iPSCs), identifying CDH2 as a therapeutically druggable leukemia-promoting factor.(1)
format Online
Article
Text
id pubmed-9418842
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-94188422022-08-28 Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche Borbaran-Bravo, Natalia Arreba-Tutusaus, Patricia Ritter, Malte U. Nasri, Masoud Klimiankou, Maksim Skokowa, Julia Cell Rep Med Preview Most studies on leukemia focus on leukemia cells as isolated objects without considering the bone marrow niche. Pal et al. have recreated the bone marrow niche using induced pluripotent stem cells (iPSCs), identifying CDH2 as a therapeutically druggable leukemia-promoting factor.(1) Elsevier 2022-08-16 /pmc/articles/PMC9418842/ /pubmed/35977470 http://dx.doi.org/10.1016/j.xcrm.2022.100724 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Borbaran-Bravo, Natalia
Arreba-Tutusaus, Patricia
Ritter, Malte U.
Nasri, Masoud
Klimiankou, Maksim
Skokowa, Julia
Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title_full Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title_fullStr Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title_full_unstemmed Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title_short Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche
title_sort regenerative medicine meets translational oncology: modeling leukemic bone marrow niche
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418842/
https://www.ncbi.nlm.nih.gov/pubmed/35977470
http://dx.doi.org/10.1016/j.xcrm.2022.100724
work_keys_str_mv AT borbaranbravonatalia regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche
AT arrebatutusauspatricia regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche
AT rittermalteu regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche
AT nasrimasoud regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche
AT klimiankoumaksim regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche
AT skokowajulia regenerativemedicinemeetstranslationaloncologymodelingleukemicbonemarrowniche

Ejemplares similares