Prostaglandin F2α and angiotensin II type 1 receptors exhibit differential cognate G protein coupling regulation

Promiscuous G protein–coupled receptors (GPCRs) engage multiple Gα subtypes with different efficacies to propagate signals in cells. A mechanistic understanding of Gα selectivity by GPCRs is critical for therapeutic design, since signaling can be restrained by ligand–receptor complexes to preferenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Sedki, Dana, Cho, Aaron, Cao, Yubo, Nikolajev, Ljiljana, Atmuri, N. D. Prasad, Lubell, William D., Laporte, Stéphane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418914/
https://www.ncbi.nlm.nih.gov/pubmed/35872018
http://dx.doi.org/10.1016/j.jbc.2022.102294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418914/
https://www.ncbi.nlm.nih.gov/pubmed/35872018
http://dx.doi.org/10.1016/j.jbc.2022.102294

Ejemplares similares