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Prostaglandin F2α and angiotensin II type 1 receptors exhibit differential cognate G protein coupling regulation
Promiscuous G protein–coupled receptors (GPCRs) engage multiple Gα subtypes with different efficacies to propagate signals in cells. A mechanistic understanding of Gα selectivity by GPCRs is critical for therapeutic design, since signaling can be restrained by ligand–receptor complexes to preferenti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418914/ https://www.ncbi.nlm.nih.gov/pubmed/35872018 http://dx.doi.org/10.1016/j.jbc.2022.102294 |