Preclinical safety and efficacy of lentiviral-mediated gene therapy for leukocyte adhesion deficiency type I

Leukocyte adhesion deficiency type I (LAD-I) is a primary immunodeficiency caused by mutations in the ITGB2 gene, which encodes for the CD18 subunit of β(2)-integrins. Deficient expression of β(2)-integrins results in impaired neutrophil migration in response to bacterial and fungal infections. Usin...

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Detalles Bibliográficos
Autores principales: Mesa-Núñez, Cristina, Damián, Carlos, Fernández-García, María, Díez, Begoña, Rao, Gayatri, Schwartz, Jonathan D., Law, Ken M., Sevilla, Julián, Río, Paula, Yáñez, Rosa, Bueren, Juan A., Almarza, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418989/
https://www.ncbi.nlm.nih.gov/pubmed/36092365
http://dx.doi.org/10.1016/j.omtm.2022.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418989/
https://www.ncbi.nlm.nih.gov/pubmed/36092365
http://dx.doi.org/10.1016/j.omtm.2022.07.015

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