Cargando…

Sustained Release of Tacrolimus From a Topical Drug Delivery System Promotes Corneal Reinnervation

PURPOSE: Corneal nerve fibers provide sensation and maintain the epithelial renewal process. Insufficient corneal innervation can cause neurotrophic keratopathy. Here, topically delivered tacrolimus is evaluated for its therapeutic potential to promote corneal reinnervation in rats. METHODS: A compa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daeschler, Simeon C., Mirmoeini, Kaveh, Gordon, Tessa, Chan, Katelyn, Zhang, Jennifer, Ali, Asim, Feinberg, Konstantin, Borschel, Gregory H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Cornea & External Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419461/ https://www.ncbi.nlm.nih.gov/pubmed/35984668 http://dx.doi.org/10.1167/tvst.11.8.20

Ejemplares similares

VP6: Sustained Topical Release of Tacrolimus Promotes Corneal Reinnervation in Rats
por: Daeschler, Simeon C., et al.
Publicado: (2022)

Schwann Cells Are Key Regulators of Corneal Epithelial Renewal
por: Mirmoeini, Kaveh, et al.
Publicado: (2023)

Therapeutic Ultrasound for Topical Corneal Delivery of Macromolecules
por: Almogbil, Hanaa H., et al.
Publicado: (2022)

Topical Ripasudil for the Treatment of Primary Corneal Endothelial Degeneration in Dogs
por: Michalak, Sarah R., et al.
Publicado: (2022)

The Effect of Anti-Inflammatory Topical Ophthalmic Treatments on In Vitro Corneal Epithelial Cells
por: Sella, Ruti, et al.
Publicado: (2022)

Topical Losartan Decreases Myofibroblast Generation But Not Corneal Opacity After Surface Blast-Simulating Irregular PTK in Rabbits
por: Sampaio, Lycia Pedral, et al.
Publicado: (2023)

Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury
por: Sampaio, Lycia Pedral, et al.
Publicado: (2022)

Norepinephrine as an Enhancer Promoting Corneal Penetration of Riboflavin for Transepithelial Corneal Crosslinking
por: Liu, Guoying, et al.
Publicado: (2023)

Effect of Corneal Collagen Cross-Linking on Subsequent Corneal Fungal Infection in Rats
por: Peng, Fangli, et al.
Publicado: (2023)

How Modifications of Corneal Cross-Linking Protocols Influence Corneal Resistance to Enzymatic Digestion and Treatment Depth
por: Kowalska, Malwina, et al.
Publicado: (2023)

Heritability of Corneal Parameters in Nuclear Families With Keratoconus
por: Wang, Yawen, et al.
Publicado: (2022)

Corneal Biomechanical Characteristics in Osteogenesis Imperfecta With Collagen Defect
por: Chou, Chien-Chih, et al.
Publicado: (2023)

Corticosteroid–Antibiotic Interactions in Bacteria that Cause Corneal Infection
por: Lee, Hun, et al.
Publicado: (2023)

Biomechanics of a Plant-Derived Sealant for Corneal Injuries
por: Liu, Betty S., et al.
Publicado: (2023)

Effect of Magnetic Microparticles on Cultivated Human Corneal Endothelial Cells
por: Park, Joo-Hee, et al.
Publicado: (2023)

Identification of the Vibrational Optical Coherence Tomography Corneal Cellular Peak
por: Daher, Nathalie D., et al.
Publicado: (2023)

Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing
por: Mahmood, Nasif, et al.
Publicado: (2023)

Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits
por: Cousins, Henry C., et al.
Publicado: (2023)

Establishing a Mouse Model of Chlorpromazine-Induced Corneal Trigeminal Denervation
por: Lin, Xiongshi, et al.
Publicado: (2023)

Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques (Macaca mulatta)
por: Casanova, M. Isabel, et al.
Publicado: (2022)

A Novel Riboflavin Formulation for Corneal Delivery Without Damaging Epithelial Cells
por: Yamagata, Yutaka, et al.
Publicado: (2023)

In Vivo Determination of the Human Corneal Elastic Modulus Using Vibrational Optical Coherence Tomography
por: Crespo, Marcos A., et al.
Publicado: (2022)

Corneal Neuro-Regenerative Effect of Transcutaneous Electrical Stimulation in Rabbit Lamellar Keratectomy Model
por: Yoo, Young-Sik, et al.
Publicado: (2022)

Assessing Age-Related Changes in Corneal Densitometry Parameters With Anterior Segment OCT Speckle
por: Fojcik, Aleksandra, et al.
Publicado: (2023)

In Situ-Forming Collagen-Hyaluronate Semi-Interpenetrating Network Hydrogel Enhances Corneal Defect Repair
por: Chen, Fang, et al.
Publicado: (2022)

Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study
por: Kirby, Mitchell A., et al.
Publicado: (2023)

Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) for Postoperative Pain After Photorefractive Keratectomy
por: Thompson, Vance, et al.
Publicado: (2023)

Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants
por: Stasi, Kalliopi, et al.
Publicado: (2022)

The Role of Sensory Innervation in Homeostatic and Injury-Induced Corneal Epithelial Renewal
por: Feinberg, Konstantin, et al.
Publicado: (2023)

Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography
por: Lawman, Samuel, et al.
Publicado: (2022)

Titanium Powder 3D-Printing Technology for a Novel Keratoprosthesis in Alkali-Burned Rabbits
por: Magalhães, Otavio de Azevedo, et al.
Publicado: (2022)

Role of Monocytes/Macrophages in the Etiology of Bullous Keratopathy After Argon Laser Iridotomy
por: Yamagami, Satoru, et al.
Publicado: (2022)

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation
por: Ho, Tsung-Chuan, et al.
Publicado: (2022)

Carbon Nanostructures for Ocular Tissue Reinforcement
por: Silvestre, Joaquin, et al.
Publicado: (2022)

Virulence Genes of Staphylococcus aureus Associated With Keratitis, Conjunctivitis, and Contact Lens–Associated Inflammation
por: Afzal, Madeeha, et al.
Publicado: (2022)

Changes in Rat Scleral Collagen Structure Induced by UVA–Riboflavin Crosslinking at Various Tissue Depths in Whole Globe Versus Scleral Patch
por: Miao, Yuan, et al.
Publicado: (2022)

Effect of Recombinant Human Lubricin on Model Tear Film Stability
por: Cui, Kiara W., et al.
Publicado: (2022)

Feasibility of Magnetic Levator Prosthesis Frame Customization Using Craniofacial Scans and 3-D Printing
por: Houston, Kevin E., et al.
Publicado: (2022)

Ocular Surface Immune Cell Profiles in Contact Lens–Induced Discomfort
por: Nair, Archana Padmanabhan, et al.
Publicado: (2022)

Automated Image Threshold Method Comparison for Conjunctival Vessel Quantification on Optical Coherence Tomography Angiography
por: Binotti, William W., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a41fvhtu2m75g8oetfbb36c6t0