Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau

Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative disorders. Here we develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enable age-dependent quantitative measurement of...

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Detalles Bibliográficos
Autores principales: Asadzadeh, Jamshid, Ruchti, Evelyne, Jiao, Wei, Limoni, Greta, MacLachlan, Catherine, Small, Scott A., Knott, Graham, Santa-Maria, Ismael, McCabe, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420134/
https://www.ncbi.nlm.nih.gov/pubmed/36030267
http://dx.doi.org/10.1038/s41467-022-32683-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420134/
https://www.ncbi.nlm.nih.gov/pubmed/36030267
http://dx.doi.org/10.1038/s41467-022-32683-5

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