Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways

Hyperthyroidism is associated with cardiac hypertrophy, fibrosis, and increased risk of cardiovascular mortality. Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mechanisms, i...

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Detalles Bibliográficos
Autores principales: Khamis, Tarek, Alsemeh, Amira Ebrahim, Abdullah, Doaa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420135/
https://www.ncbi.nlm.nih.gov/pubmed/36030321
http://dx.doi.org/10.1038/s41598-022-18860-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420135/
https://www.ncbi.nlm.nih.gov/pubmed/36030321
http://dx.doi.org/10.1038/s41598-022-18860-y

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