The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1

Suppression of nascent DNA degradation has emerged as an essential role of the BRCA pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible for both resection of reversed replication forks, and accumulation of single stranded DNA gaps behind forks. Here, we show that...

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Detalles Bibliográficos
Autores principales: Dhoonmoon, Ashna, Nicolae, Claudia M., Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420157/
https://www.ncbi.nlm.nih.gov/pubmed/36030235
http://dx.doi.org/10.1038/s41467-022-32756-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420157/
https://www.ncbi.nlm.nih.gov/pubmed/36030235
http://dx.doi.org/10.1038/s41467-022-32756-5

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