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The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
Suppression of nascent DNA degradation has emerged as an essential role of the BRCA pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible for both resection of reversed replication forks, and accumulation of single stranded DNA gaps behind forks. Here, we show that...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420157/ https://www.ncbi.nlm.nih.gov/pubmed/36030235 http://dx.doi.org/10.1038/s41467-022-32756-5 |