Cargando…

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New 8-methyl-4-oxo-1,4-dihydroquinoline-3-carbohydrazides as Potential Anti-HIV Agents

BACKGROUND: The development of a highly safe and potent scaffold is a significant challenge in anti-HIV drug discovery. OBJECTIVES: This study aimed at developing a novel series of anti-HIV agents based on HIV integrase inhibitor pharmacophores. METHODS: A novel series of 8-methyl-4-oxo-1,4-dihydroq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alemi, Mehrdad, Kamali, Fatemeh, Vahabpour Roudsari, Rouhollah, Hajimahdi, Zahra, Zarghi, Afshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Brieflands 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420234/ https://www.ncbi.nlm.nih.gov/pubmed/36060911 http://dx.doi.org/10.5812/ijpr-123962

Ejemplares similares

Design, Synthesis, Molecular Modeling Studies and Biological Evaluation of N′-Arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazide Derivatives as Novel Anti-HCV Agents
por: Mahboubi Rabbani, Sayyed Mohammad Ismaeil, et al.
Publicado: (2019)

Design, Synthesis, Docking Study, and Biological Evaluation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide Derivatives as Anti-HIV-1 and Antibacterial Agents.
por: Abdollahi, Omid, et al.
Publicado: (2022)

4-(1-Benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic Acid Derivatives: Design, Synthesis and Anti-HIV-1 Activity
por: Karimi, Nafiseh, et al.
Publicado: (2021)

Design, Synthesis, Molecular Modeling Study and Biological Evaluation of New N'-Arylidene-pyrido [2,3-d]pyrimidine-5-carbohydrazide Derivatives as Anti-HIV-1 Agents
por: Ebrahimzadeh, Elnaz, et al.
Publicado: (2019)

QSAR Study on Anti-HIV-1 Activity of 4-Oxo-1,4-dihydroquinoline and 4-Oxo-4H-pyrido[1,2-a]pyrimidine Derivatives Using SW-MLR, Artificial Neural Network and Filtering Methods
por: Hajimahdi, Zahra, et al.
Publicado: (2015)

Design, Synthesis, Docking Study and Biological Evaluation of 4-Hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide Derivatives as Anti-HIV Agents
por: Imani, Ali, et al.
Publicado: (2021)

(E)-1-Ethyl-4-oxo-N′-(4-pyridylmethylene)-1,4-dihydroquinoline-3-carbohydrazide
por: da C. Santos, Fernanda, et al.
Publicado: (2009)

Ethyl 4-oxo-8-trifluoromethyl-1,4-dihydroquinoline-3-carboxylate
por: Garudachari, B., et al.
Publicado: (2012)

Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors
por: Zarghi, Afshin, et al.
Publicado: (2014)

Ethyl 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
por: Ishikawa, Yoshinobu, et al.
Publicado: (2014)

Study on the regioselectivity of the N-ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide
por: Batalha, Pedro N, et al.
Publicado: (2019)

QSAR Analysis for Some 1, 2-Benzisothiazol-3-one Derivatives as Caspase-3 Inhibitors by Stepwise MLR Method
por: Hajimahdi, Zahra, et al.
Publicado: (2016)

3-Ethoxymethyl-1,4-dihydroquinolin-4-one
por: Zaghary, Wafaa A., et al.
Publicado: (2012)

Crystal structure of ethyl 8-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate
por: Ishikawa, Yoshinobu, et al.
Publicado: (2015)

1-Ethyl-6-fluoro-7-(4-methylpiperazin-4-ium-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate hexahydrate
por: An, Zhe, et al.
Publicado: (2008)

N′-[(E)-Benzylidene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide
por: Deeba, Farah, et al.
Publicado: (2009)

Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity
por: Hajimahdi, Zahra, et al.
Publicado: (2016)

1-Ethyl-N′-[(E)-4-hydroxybenzylidene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide
por: Deeba, Farah, et al.
Publicado: (2009)

Molecular Docking and QSAR Study of 2-Benzoxazolinone, Quinazoline and Diazocoumarin Derivatives as Anti-HIV-1 Agents
por: Faghihi, Kamyar, et al.
Publicado: (2019)

Methyl 2-(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)acetate
por: Shishkina, Svitlana V., et al.
Publicado: (2010)

Ethyl 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
por: Sun, Hong-shun, et al.
Publicado: (2011)

Aquabis[1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylato]zinc(II) dihydrate
por: Qi, Wei, et al.
Publicado: (2008)

Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives as Selective Cyclooxygenase-2 Inhibitors
por: Sabakhi, Iman, et al.
Publicado: (2015)

Ethyl 1-(2,4-dichlorobenzyl)-4-oxo-7-trifluoromethyl-1,4-dihydroquinoline-3-carboxylate
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
por: Wang, De-Cai, et al.
Publicado: (2008)

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate
por: Al-Qawasmeh, Raed A.
Publicado: (2012)

A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives
por: Gill, Muhammad Shoaib Ali, et al.
Publicado: (2022)

N′-[(2Z)-4-Oxo-4-phenylbut-2-en-2-yl]pyridine-4-carbohydrazide
por: Bikas, Rahman, et al.
Publicado: (2012)

Ethyl 2-(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)acetate
por: Ukrainets, Igor V., et al.
Publicado: (2009)

1-Cyclopropyl-6-fluoro-7-(4-nitrosopiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
por: Li, Tao, et al.
Publicado: (2009)

Poly[[[[1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylato]cadmium]-μ-benzene-1,4-dicarboxylato] trihydrate]
por: Kang, Xin-Ping, et al.
Publicado: (2010)

QSAR Modeling of COX -2 Inhibitory Activity of Some Dihydropyridine and Hydroquinoline Derivatives Using Multiple Linear Regression (MLR) Method
por: Akbari, Somaye, et al.
Publicado: (2017)

Bis[1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylato-κ(2) O (3),O (4)]copper(II)
por: Qi, Wei, et al.
Publicado: (2009)

Ethyl 7-amino-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate monohydrate
por: Pan, Jia, et al.
Publicado: (2008)

HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies
por: Mahboubi-Rabbani, Mohammad, et al.
Publicado: (2021)

Ethyl 6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylate
por: Khan, F. Nawaz, et al.
Publicado: (2009)

7-{4-[(1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
por: Wang, Shuo, et al.
Publicado: (2012)

5-Methyl-N′-(3-nitrobenzylidene)isoxazole-4-carbohydrazide
por: Jin, Yan-Xian
Publicado: (2009)

Diaquabis[1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylato]magnesium(II) hexahydrate
por: Wen, Ji-Feng, et al.
Publicado: (2010)

Tetraaquabis(2-oxo-1,2-dihydroquinoline-4-carboxylato-κO (4))nickel(II)
por: Yuan, Gang, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_fdrudejlicmshgov8o0u032803