MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes

BACKGROUND: Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myocardial injury and heart dysfunction in streptozocin (STZ)-induced diabetic mice,...

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Detalles Bibliográficos
Autores principales: Cao, Ting, Ni, Rui, Ding, Weimin, Ji, Xiaoyun, Li, Lan, Liao, Guangneng, Lu, Yanrong, Fan, Guo-Chang, Zhang, Zhuxu, Peng, Tianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420252/
https://www.ncbi.nlm.nih.gov/pubmed/36030201
http://dx.doi.org/10.1186/s12933-022-01602-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420252/
https://www.ncbi.nlm.nih.gov/pubmed/36030201
http://dx.doi.org/10.1186/s12933-022-01602-9

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