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Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells

A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase or alternative lengthening of telomeres exhibit aggressive growth characteristics that lead to poor outcomes, wherea...

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Detalles Bibliográficos
Autores principales: Yu, Eun Young, Cheung, Nai-Kong V., Lue, Neal F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420296/
https://www.ncbi.nlm.nih.gov/pubmed/36030273
http://dx.doi.org/10.1186/s13045-022-01337-w