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CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer

In this study, we investigate the synergistic effect of gemcitabine (Gem) and a novel DNA vaccine in the treatment of pancreatic cancer in mice and explore the anti-tumor mechanism of this combination therapy. Fibroblast activation protein α-expressing cancer-associated fibroblasts (FAPα(+) CAFs), a...

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Detalles Bibliográficos
Autores principales: Geng, Fei, Dong, Ling, Bao, Xin, Guo, Qianqian, Guo, Jie, Zhou, Yi, Yu, Bin, Wu, Hui, Wu, Jiaxin, Zhang, Haihong, Yu, Xianghui, Kong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420428/
https://www.ncbi.nlm.nih.gov/pubmed/36090474
http://dx.doi.org/10.1016/j.omto.2022.07.008