Cargando…

CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer

In this study, we investigate the synergistic effect of gemcitabine (Gem) and a novel DNA vaccine in the treatment of pancreatic cancer in mice and explore the anti-tumor mechanism of this combination therapy. Fibroblast activation protein α-expressing cancer-associated fibroblasts (FAPα(+) CAFs), a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Fei, Dong, Ling, Bao, Xin, Guo, Qianqian, Guo, Jie, Zhou, Yi, Yu, Bin, Wu, Hui, Wu, Jiaxin, Zhang, Haihong, Yu, Xianghui, Kong, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420428/ https://www.ncbi.nlm.nih.gov/pubmed/36090474 http://dx.doi.org/10.1016/j.omto.2022.07.008

Ejemplares similares

ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma
por: Takhsha, Farnaz Sedigheh, et al.
Publicado: (2021)

A novel in vitro model of metastasis supporting passive shedding hypothesis from murine pancreatic cancer Panc-02
por: Krzykawski, M. P., et al.
Publicado: (2019)

Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells
por: Sood, Nimil, et al.
Publicado: (2013)

Pancreatic ductal adenocarcinoma cells regulated the gemcitabine‐resistance function of CAFs by LINC00460
por: Zhu, Xiao‐Xu, et al.
Publicado: (2022)

Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine
por: Yang, Xiaoping, et al.
Publicado: (2019)

Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells
por: He, Ji, et al.
Publicado: (2023)

Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse
por: Guo, Qianqian, et al.
Publicado: (2020)

Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer
por: Geng, Xinglong, et al.
Publicado: (2021)

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer
por: Porcelli, Letizia, et al.
Publicado: (2019)

Gemcitabine-loaded albumin nanospheres (GEM-ANPs) inhibit PANC-1 cells in vitro and in vivo
por: Li, Ji, et al.
Publicado: (2013)

Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC-1 cells
por: Pak, Pyo June, et al.
Publicado: (2021)

Combination therapy of irreversible electroporation and cytokine-induced killer cells for treating mice bearing panc02 pancreatic-cancer xenografts
por: Wang, Baohua, et al.
Publicado: (2023)

Combination L-Glutamine with Gemcitabine and Nab-Paclitaxel in Treatment-Naïve Advanced Pancreatic Cancer: The Phase I GlutaPanc Study Protocol
por: Gong, Jun, et al.
Publicado: (2023)

THE PANC 3 SCORE PREDICTING SEVERITY OF ACUTE PANCREATITIS
por: BEDUSCHI, Murilo Gamba, et al.
Publicado: (2016)

Fast DNA Vaccination Strategy Elicits a Stronger Immune Response Dependent on CD8(+)CD11c(+) Cell Accumulation
por: Liu, Chenlu, et al.
Publicado: (2021)

Assessment of PANC3 Score in Predicting Severity of Acute Pancreatitis
por: Shah, Avreen Singh, et al.
Publicado: (2017)

Cancer Stem-Like Cells Enriched in Panc-1 Spheres Possess Increased Migration Ability and Resistance to Gemcitabine
por: Yin, Tao, et al.
Publicado: (2011)

Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)
por: Zhu, Xiang-Yu, et al.
Publicado: (2012)

Quality of life study of patients with unresectable locally advanced or metastatic pancreatic adenocarcinoma treated with gemcitabine+nab-paclitaxel versus gemcitabine alone: AX-PANC-SY001, a randomized phase-2 study
por: Yalcin, Suayib, et al.
Publicado: (2020)

Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus
por: LIU, LING, et al.
Publicado: (2013)

P86 PANC Study - Pancreatitis: A National Cohort Study
Publicado: (2021)

JWA gene regulates PANC-1 pancreatic cancer cell behaviors through MEK-ERK1/2 of the MAPK signaling pathway
por: WU, YUAN-YUAN, et al.
Publicado: (2014)

Ellagic acid inhibits the proliferation of human pancreatic carcinoma PANC-1 cells in vitro and in vivo
por: Cheng, Hao, et al.
Publicado: (2017)

Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice
por: Yang, Ping, et al.
Publicado: (2019)

Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling
por: Wang, Bili, et al.
Publicado: (2019)

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells
por: Khan, Muhammad, et al.
Publicado: (2012)

Effects of disulfiram on apoptosis in PANC-1 human pancreatic cancer cell line
por: Dastjerdi, M. Nikbakht, et al.
Publicado: (2014)

Cytotoxic effect of pyocyanin on human pancreatic cancer cell line (Panc-1)
por: Moayedi, Aylin, et al.
Publicado: (2018)

Metabolic characterization of invaded cells of the pancreatic cancer cell line, PANC‐1
por: Fujita, Mayumi, et al.
Publicado: (2017)

Emerging Contribution of PancRNAs in Cancer
por: Mercatelli, Neri, et al.
Publicado: (2020)

Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63
por: Ozaki, Toshinori, et al.
Publicado: (2016)

Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells
por: Hofer, M D, et al.
Publicado: (2004)

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death
por: Ueda, Jun-ya, et al.
Publicado: (2013)

CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns
por: van Haren, Simon D., et al.
Publicado: (2022)

A Quick Guide to CAF Subtypes in Pancreatic Cancer
por: Brichkina, Anna, et al.
Publicado: (2023)

Chinese Propolis Suppressed Pancreatic Cancer Panc-1 Cells Proliferation and Migration via Hippo-YAP Pathway
por: Tao, Lingchen, et al.
Publicado: (2021)

Establishment and characterization of the gemcitabine-resistant human pancreatic cancer cell line SW1990/gemcitabine
por: Yu, Yue, et al.
Publicado: (2019)

Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells
por: Lu, Chueh-Hsuan, et al.
Publicado: (2018)

Effect of quercetin on apoptosis of PANC-1 cells
por: Lee, Joo Hyun, et al.
Publicado: (2013)

Silencing of Carboxypeptidase E expression inhibits proliferation and invasion of Panc-1 pancreatic cancer cells
por: Lou, Hong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_etvhu70dbsfkuclt6llgi3pip8