Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

Biocompatible Poly(N-isopropylacrylamide) (PNIPAM) nanogels (NGs) were developed at 40–65 nm to deliver Trans-Tephrostachin (TT) in zebrafish brain. Neurospecific PNIPAM NGs are functionalized with polysorbate 80 (PS80) to overcome the Blood Brain Barrier (BBB). The TT loaded with NG (NG + TT) was c...

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Detalles Bibliográficos
Autores principales: Arjun, Pitchai, Freeman, Jennifer L., Kannan, Rajaretinam Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420489/
https://www.ncbi.nlm.nih.gov/pubmed/36042734
http://dx.doi.org/10.1016/j.heliyon.2022.e10237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420489/
https://www.ncbi.nlm.nih.gov/pubmed/36042734
http://dx.doi.org/10.1016/j.heliyon.2022.e10237

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