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Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibody

Respiratory transmission of SARS-CoV-2 is considered to be the major dissemination route for COVID-19, therefore, mucosal immune responses have great importance in preventing SARS-CoV-2 from infection. In this study, we constructed a recombinant Vaccinia virus (VV) harboring trimeric receptor-bindin...

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Detalles Bibliográficos
Autores principales: Cao, Xiaoling, Zai, Junjie, Zhao, Qingzhen, Xie, Lilan, Li, Yaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420698/
https://www.ncbi.nlm.nih.gov/pubmed/36055873
http://dx.doi.org/10.1016/j.vaccine.2022.08.054