Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase

Immune cells and the cytokines they produce are important mediators of the transition from colitis to colon cancer, but the mechanisms mediating this disease progression are poorly understood. Interferon gamma (IFN-γ) is known to contribute to the pathogenesis of colitis through immune modulatory me...

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Detalles Bibliográficos
Autores principales: Choi, Sung Hee, Huang, Alex Y., Letterio, John J., Kim, Byung-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420841/
https://www.ncbi.nlm.nih.gov/pubmed/36045676
http://dx.doi.org/10.3389/fimmu.2022.932412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420841/
https://www.ncbi.nlm.nih.gov/pubmed/36045676
http://dx.doi.org/10.3389/fimmu.2022.932412

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