Cargando…

Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase

Immune cells and the cytokines they produce are important mediators of the transition from colitis to colon cancer, but the mechanisms mediating this disease progression are poorly understood. Interferon gamma (IFN-γ) is known to contribute to the pathogenesis of colitis through immune modulatory me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Sung Hee, Huang, Alex Y., Letterio, John J., Kim, Byung-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420841/ https://www.ncbi.nlm.nih.gov/pubmed/36045676 http://dx.doi.org/10.3389/fimmu.2022.932412

Ejemplares similares

Genetic Variation in 15-Hydroxyprostaglandin Dehydrogenase and Colon Cancer Susceptibility
por: Thompson, Cheryl L., et al.
Publicado: (2013)

Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma
por: Kang, Jae Hyun, et al.
Publicado: (2014)

miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer
por: Monteleone, Nicholas J., et al.
Publicado: (2019)

Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
por: Jang, Tae Jung, et al.
Publicado: (2008)

15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue
por: Yang, Dong-Hoon, et al.
Publicado: (2017)

Downregulation of 15-hydroxyprostaglandin dehydrogenase in hormone-resistant breast cancer
por: Cummings, M, et al.
Publicado: (2008)

15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia
por: Xu, Yunfei, et al.
Publicado: (2022)

15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury
por: Kim, Byeong Woo, et al.
Publicado: (2021)

Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma
por: Yang, Jee Eun, et al.
Publicado: (2014)

Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition
por: Satapathy, Shakti Ranjan, et al.
Publicado: (2020)

Prognostic Implication of 15-Hydroxyprostaglandin Dehydrogenase Down-Regulation in Patients with Colorectal Cancer
por: Kang, Pil Sung, et al.
Publicado: (2012)

15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
por: KIM, HAK-JAE, et al.
Publicado: (2015)

Sex Differential in 15‐Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms
por: Chalouhi, Nohra, et al.
Publicado: (2017)

In-vitro Wound Healing Effect of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor from Plant
por: Karna, Sandeep
Publicado: (2017)

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury
por: Yao, Lu, et al.
Publicado: (2017)

15-Hydroxyprostaglandin Dehydrogenase in Colorectal Mucosa as a Potential Biomarker for Predicting Colorectal Neoplasms
por: Lee, Hyo Jeong, et al.
Publicado: (2013)

miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD)
por: Huang, Xiaoyong, et al.
Publicado: (2015)

11-Oxoeicosatetraenoic Acid Is a Cyclooxygenase-2/15-Hydroxyprostaglandin Dehydrogenase-Derived Antiproliferative Eicosanoid
por: Liu, Xiaojing, et al.
Publicado: (2011)

Effect of 15-hydroxyprostaglandin dehydrogenase gene on the proliferation of gastric cancer cell murine forestomach carcinoma
por: LI, LIHUA, et al.
Publicado: (2014)

MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma
por: Park, Young Soo, et al.
Publicado: (2018)

A potential anti-tumor effect of leukotriene C(4) through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells
por: Mehdawi, Lubna M., et al.
Publicado: (2017)

Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(−/−)) mice due to requirement for embryo 15-HPGD activity
por: Roizen, Jeffrey D., et al.
Publicado: (2019)

High-Affinity Inhibitors of Human NAD(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships
por: Niesen, Frank H., et al.
Publicado: (2010)

Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis
por: LI, YING, et al.
Publicado: (2014)

Downregulation of 15‐hydroxyprostaglandin dehydrogenase by interleukin‐1β from activated macrophages leads to poor prognosis in pancreatic cancer
por: Arima, Kota, et al.
Publicado: (2018)

Compound Heterozygous Pathogenic Variants of the 15-Hydroxyprostaglandin Dehydrogenase Gene in a Patient With Hypertrophic Osteoarthropathy: First Case in Korea
por: Ryu, Mi Ra, et al.
Publicado: (2019)

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4
por: Choi, Sung Hee, et al.
Publicado: (2020)

Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenase
por: Tanigawa, Tetsuya, et al.
Publicado: (2011)

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer
por: Volpato, Milene, et al.
Publicado: (2020)

MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma
por: He, Qianting, et al.
Publicado: (2016)

The Enzyme 15-Hydroxyprostaglandin Dehydrogenase Inhibits a Shift to the Mesenchymal Pattern of Trophoblasts and Decidual Stromal Cells Accompanied by Prostaglandin Transporter in Preeclampsia
por: Pang, Huiyuan, et al.
Publicado: (2023)

15-Deoxy-Δ(12,14)-prostaglandin J(2) Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
por: Park, Jong-Min, et al.
Publicado: (2019)

15-Deoxy-Δ(12,14)-prostaglandin J2 Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
por: Park, Jong-Min, et al.
Publicado: (2019)

Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
por: Wu, Ruxing, et al.
Publicado: (2017)

MicroRNA-218 promotes prostaglandin E2 to inhibit osteogenic differentiation in synovial mesenchymal stem cells by targeting 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
por: Cong, Ruijun, et al.
Publicado: (2017)

Overexpression of 15-Hydroxyprostaglandin Dehydrogenase Inhibits A549 Lung Adenocarcinoma Cell Growth via Inducing Cell Cycle Arrest and Inhibiting Epithelial-Mesenchymal Transition
por: Wang, Weixuan, et al.
Publicado: (2021)

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
por: Apriamashvili, Georgi, et al.
Publicado: (2022)

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts
por: Rottman, Martin, et al.
Publicado: (2008)

Cigarette Smoking Triggers Colitis by IFN-γ(+) CD4(+) T Cells
por: Lee, Gihyun, et al.
Publicado: (2017)

Disruption of Smad4 Expression in T Cells Leads to IgA Nephropathy-Like Manifestations
por: Inoshita, Hiroyuki, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_v7dbkhmea10kukled9j63d45qk