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EZH2 restricts Tcf7 DNA methylation and promotes T(FH) differentiation during acute viral infection
Follicular helper T (T(FH)) cells provide specialized help for B cells to ensure optimal humoral immunity. The histone methyltransferase EZH2, as a chromatin repressor, secures the T(FH) differentiation by promoting T(FH) lineage associated gene expression during acute viral infection, including Tcf...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420843/ https://www.ncbi.nlm.nih.gov/pubmed/36045674 http://dx.doi.org/10.3389/fimmu.2022.942465 |