EZH2 restricts Tcf7 DNA methylation and promotes T(FH) differentiation during acute viral infection

Follicular helper T (T(FH)) cells provide specialized help for B cells to ensure optimal humoral immunity. The histone methyltransferase EZH2, as a chromatin repressor, secures the T(FH) differentiation by promoting T(FH) lineage associated gene expression during acute viral infection, including Tcf...

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Detalles Bibliográficos
Autores principales: Luo, Yuan, Li, Dan, Xie, Luoyingzi, Lei, Shun, Chen, Xiangyu, Wang, Cong, Yao, Dong, Li, Lin, Fang, Jingyi, Chen, Cheng, Yuan, Shijie, Li, Fei, Xie, Xiaorong, Zhang, Yan, Li, Zhirong, Hu, Li, Tang, Jianfang, Ye, Lilin, Wei, Zhengping, He, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420843/
https://www.ncbi.nlm.nih.gov/pubmed/36045674
http://dx.doi.org/10.3389/fimmu.2022.942465

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