Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes

Single-strand breaks (SSBs) represent one of the most common types of DNA damage, yet not much is known about the genome landscapes of this type of DNA lesions in mammalian cells. Here, we found that SSBs are more likely to occur in certain positions of the human genome—SSB hotspots—in different cel...

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Detalles Bibliográficos
Autores principales: Cao, Huifen, Zhang, Yufei, Cai, Ye, Tang, Lu, Gao, Fan, Xu, Dongyang, Kapranov, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420937/
https://www.ncbi.nlm.nih.gov/pubmed/36046604
http://dx.doi.org/10.3389/fmolb.2022.895795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420937/
https://www.ncbi.nlm.nih.gov/pubmed/36046604
http://dx.doi.org/10.3389/fmolb.2022.895795

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