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Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2

Human tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the synthesis of serotonin. Its dysfunction has been implicated in various psychiatric disorders such as depression, autism, and bipolar disorder. TPH2 is typically decreased in stability and catalytic activity in patients; thus, s...

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Detalles Bibliográficos
Autores principales: Zhu, Kongfu, Liu, Chao, Gao, Yuanzhu, Lu, Jianping, Wang, Daping, Zhang, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420949/
https://www.ncbi.nlm.nih.gov/pubmed/36046836
http://dx.doi.org/10.3389/fphar.2022.907437