Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection via pleiotropic effects including antio...

Descripción completa

Detalles Bibliográficos
Autores principales: Papatheodorou, Ioanna, Makrecka-Kuka, Marina, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija, Lazou, Antigone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420994/
https://www.ncbi.nlm.nih.gov/pubmed/36046786
http://dx.doi.org/10.3389/fendo.2022.941822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420994/
https://www.ncbi.nlm.nih.gov/pubmed/36046786
http://dx.doi.org/10.3389/fendo.2022.941822

Ejemplares similares