Cargando…

Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection via pleiotropic effects including antio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papatheodorou, Ioanna, Makrecka-Kuka, Marina, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija, Lazou, Antigone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420994/ https://www.ncbi.nlm.nih.gov/pubmed/36046786 http://dx.doi.org/10.3389/fendo.2022.941822

Ejemplares similares

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
por: Kuka, Janis, et al.
Publicado: (2021)

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
por: Kuka, Janis, et al.
Publicado: (2020)

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues
por: Makrecka-Kuka, Marina, et al.
Publicado: (2017)

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia
por: Makrecka‐Kuka, Marina, et al.
Publicado: (2020)

Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism
por: Vilks, Karlis, et al.
Publicado: (2021)

Excretion of the Polymyxin Derivative NAB739 in Murine Urine
por: Vaara, Martti, et al.
Publicado: (2020)

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity
por: Makarova, Elina, et al.
Publicado: (2019)

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
por: Liepinsh, Edgars, et al.
Publicado: (2020)

Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19
por: Vilskersts, Reinis, et al.
Publicado: (2021)

Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production
por: Papatheodorou, Ioanna, et al.
Publicado: (2021)

The brain acylcarnitine profile depends on nutritional state
por: Svalbe, Baiba, et al.
Publicado: (2015)

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production
por: Makrecka-Kuka, Marina, et al.
Publicado: (2020)

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure
por: Videja, Melita, et al.
Publicado: (2021)

Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury
por: Kupats, Einars, et al.
Publicado: (2020)

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury
por: Vilskersts, Reinis, et al.
Publicado: (2020)

Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance
por: Makrecka-Kuka, Marina, et al.
Publicado: (2022)

Data on cardiac and vascular functionality in ex vivo and in vivo models following acute administration of trimethylamine N-oxide
por: Videja, Melita, et al.
Publicado: (2023)

High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria
por: Makrecka-Kuka, Marina, et al.
Publicado: (2015)

Editorial: Lipotoxicity, mitotoxicity, and drug targets
por: Krako Jakovljevic, Nina, et al.
Publicado: (2023)

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers
por: Videja, Melita, et al.
Publicado: (2022)

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
por: Allen, Mitchell E., et al.
Publicado: (2020)

Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels
por: Liepinsh, Edgars, et al.
Publicado: (2023)

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
por: Lin, Fei, et al.
Publicado: (2020)

Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from Pelargonium sidoides DC Root Extract
por: Jekabsone, Aiste, et al.
Publicado: (2019)

Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia
por: Veisa, Vija, et al.
Publicado: (2021)

Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice
por: Zvejniece, Liga, et al.
Publicado: (2020)

Sex-Related Effects on Cardiac Development and Disease
por: Siokatas, Georgios, et al.
Publicado: (2022)

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity
por: Zelencova-Gopejenko, Diana, et al.
Publicado: (2023)

Impact of the m.13513G>A Variant on the Functions of the OXPHOS System and Cell Retrograde Signaling
por: Kidere, Dita, et al.
Publicado: (2023)

PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
por: Wang, Chaoqun, et al.
Publicado: (2021)

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
por: Corona, Juan Carlos, et al.
Publicado: (2014)

PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function
por: Kleiner, Sandra, et al.
Publicado: (2009)

In ovo effect of Soursop (Annona muricata L.) leaf extract on hatching and post-hatch performance of Noiler chickens
por: Kuka, Timothy T., et al.
Publicado: (2023)

Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions
por: Han, Yoon-Mi, et al.
Publicado: (2020)

Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway
por: Yao, Zhilu, et al.
Publicado: (2023)

PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψ(m) Pathways by Inhibiting Pyroptosis
por: Feng, Zhencheng, et al.
Publicado: (2023)

Role of Perioperative Surgical Safety Checklist in Reducing Morbidity and Mortality among Patients: An Observational Study
por: Chhabra, Ashish, et al.
Publicado: (2019)

NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?
por: Mackenzie, Gerardo G., et al.
Publicado: (2008)

Cardiac metabolism as a driver and therapeutic target of myocardial infarction
por: Zuurbier, Coert J., et al.
Publicado: (2020)

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nbs1jeh09i83nb3qr1ld9n7dd0