Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data

Ribozymes are RNA molecules that catalyze biochemical reactions. Self-cleaving ribozymes are a common naturally occurring class of ribozymes that catalyze site-specific cleavage of their own phosphodiester backbone. In addition to their natural functions, self-cleaving ribozymes have been used to en...

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Detalles Bibliográficos
Autores principales: Beck, James D., Roberts, Jessica M., Kitzhaber, Joey M., Trapp, Ashlyn, Serra, Edoardo, Spezzano, Francesca, Hayden, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421044/
https://www.ncbi.nlm.nih.gov/pubmed/36046603
http://dx.doi.org/10.3389/fmolb.2022.893864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421044/
https://www.ncbi.nlm.nih.gov/pubmed/36046603
http://dx.doi.org/10.3389/fmolb.2022.893864

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