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Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data
Ribozymes are RNA molecules that catalyze biochemical reactions. Self-cleaving ribozymes are a common naturally occurring class of ribozymes that catalyze site-specific cleavage of their own phosphodiester backbone. In addition to their natural functions, self-cleaving ribozymes have been used to en...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421044/ https://www.ncbi.nlm.nih.gov/pubmed/36046603 http://dx.doi.org/10.3389/fmolb.2022.893864 |