Cargando…

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

The histone methyltransferase SET and MYND domain protein 2 (SMYD2) has been implicated in tumorigenesis through methylating histone H3 at lysine36 (H3K36) and some non-histone substrates. Currently, the role of SMYD2 in acute kidney injury (AKI) remains unknown. Here, we investigated the effects of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Binbin, Hou, Xiying, Liu, Mengjun, Li, Qing, Yu, Chao, Zhang, Shenglei, Wang, Yi, Wang, Jun, Zhuang, Shougang, Liu, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421052/ https://www.ncbi.nlm.nih.gov/pubmed/36046818 http://dx.doi.org/10.3389/fphar.2022.829630

Ejemplares similares

Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin‐induced acute kidney injury
por: Yu, Chao, et al.
Publicado: (2022)

Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice
por: Shen, Fengchen, et al.
Publicado: (2022)

Delayed Administration of Nintedanib Ameliorates Fibrosis Progression in CG-Induced Peritoneal Fibrosis Mouse Model
por: Cui, Binbin, et al.
Publicado: (2022)

3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression
por: Ni, Jun, et al.
Publicado: (2019)

Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation
por: Li, Jialu, et al.
Publicado: (2022)

Correction: 3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression
por: Ni, Jun, et al.
Publicado: (2019)

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
por: Yu, Chao, et al.
Publicado: (2019)

Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice
por: Liu, Xinhui, et al.
Publicado: (2023)

Preparation, structural characterization, antioxidant activity and protection against cisplatin-induced acute kidney injury by polysaccharides from the lateral root of Aconitum carmichaelii
por: Tian, Maoying, et al.
Publicado: (2022)

Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression
por: Yu, Chao, et al.
Publicado: (2021)

Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats
por: Xiong, Chongxiang, et al.
Publicado: (2021)

The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury
por: Zhou, Xun, et al.
Publicado: (2021)

Epidermal Growth Factor Receptor: A Potential Therapeutic Target for Diabetic Kidney Disease
por: Sheng, Lili, et al.
Publicado: (2021)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

Prediction of the mechanism for the combination of diallyl trisulfide and cisplatin against gastric cancer: a network pharmacology study and pharmacological evaluation
por: Lv, Huaiyou, et al.
Publicado: (2023)

New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
por: Shao, Minghai, et al.
Publicado: (2021)

Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation
por: Zhang, Difei, et al.
Publicado: (2021)

The protective mechanism of Dehydromiltirone in diabetic kidney disease is revealed through network pharmacology and experimental validation
por: Wang, Yanzhe, et al.
Publicado: (2023)

Pharmacological Inhibition of Fatty Acid-Binding Protein 4 (FABP4) Protects Against Rhabdomyolysis-Induced Acute Kidney Injury
por: Huang, Rongshuang, et al.
Publicado: (2018)

Repositioning of Lansoprazole as a Protective Agent Against Cisplatin-Induced Ototoxicity
por: Wakai, Eri, et al.
Publicado: (2022)

Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice
por: Xia, Juan, et al.
Publicado: (2022)

Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials
por: Yang, Shenglei, et al.
Publicado: (2023)

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage
por: Xiao, Zhun, et al.
Publicado: (2020)

Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion
por: Xiong, Chongxiang, et al.
Publicado: (2017)

Protein arginine methyltransferases in renal development, injury, repair, and fibrosis
por: Yu, Jianjun, et al.
Publicado: (2023)

Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2022)

Pharmacological mechanisms of Fuzheng Huayu formula for Aristolochic acid I–induced kidney fibrosis through network pharmacology
por: Wang, Fan, et al.
Publicado: (2022)

Nintedanib attenuates peritoneal fibrosis by inhibiting mesothelial‐to‐mesenchymal transition, inflammation and angiogenesis
por: Liu, Feng, et al.
Publicado: (2021)

Corrigendum: Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2023)

Histone Acetylation and Modifiers in Renal Fibrosis
por: Shen, Fengchen, et al.
Publicado: (2022)

QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology
por: Li, Meng, et al.
Publicado: (2022)

SMYD3 confers cisplatin chemoresistance of NSCLC cells in an ANKHD1-dependent manner
por: Lv, Hong-Wei, et al.
Publicado: (2021)

Integrated analysis of comprehensive metabolomics and network pharmacology to reveal the mechanisms of abelmoschus manihot (L.) medik. in the treatment of cisplatin-induced chronic kidney disease
por: Liao, Jian-Cheng, et al.
Publicado: (2022)

Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn’s Disease
por: Liu, Jinguo, et al.
Publicado: (2022)

A molecular network-based pharmacological study on the protective effect of Panax notoginseng rhizomes against renal ischemia–reperfusion injury
por: Li, Dan-Dan, et al.
Publicado: (2023)

VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury
por: Li, Yan, et al.
Publicado: (2023)

The Pharmacological Mechanism of Guchangzhixie Capsule Against Experimental Colitis
por: Yan, Jing, et al.
Publicado: (2021)

A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Chuanxiong Rhizoma in Alzheimer’s Disease
por: Zeng, Peng, et al.
Publicado: (2022)

Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy
por: Wang, Yongfang, et al.
Publicado: (2019)

Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review
por: Xie, Weijie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k7chk7u79t1ej2km8m32f06ta2