Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children

PURPOSE: To evaluate patients with multisystemic inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using optical coherence tomography angiography (OCTA) during and after resolution of inflammation to investigate the effec...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurumoğlu Incekalan, Tuğba, Celik, Umit, Tolunay, Orkun, Naz Şimdivar, Goksu Hande, Alyamaç Sukgen, Emine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421118/
https://www.ncbi.nlm.nih.gov/pubmed/36036326
http://dx.doi.org/10.1007/s10792-022-02382-7
_version_ 1784777525328609280
author Kurumoğlu Incekalan, Tuğba
Celik, Umit
Tolunay, Orkun
Naz Şimdivar, Goksu Hande
Alyamaç Sukgen, Emine
author_facet Kurumoğlu Incekalan, Tuğba
Celik, Umit
Tolunay, Orkun
Naz Şimdivar, Goksu Hande
Alyamaç Sukgen, Emine
author_sort Kurumoğlu Incekalan, Tuğba
collection PubMed
description PURPOSE: To evaluate patients with multisystemic inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using optical coherence tomography angiography (OCTA) during and after resolution of inflammation to investigate the effect of this entity on the retinal and choroidal circulation. METHODS: The study included 38 eyes of 19 patients diagnosed as having MIS-C between March 2021 and June 2021. OCTA measurements of choroidal thickness and vessel density in the radial peripapillary capillary plexus (RPCP), superficial capillary plexus (SCP), and deep capillary plexus (DCP) obtained at time of diagnosis and 60 days later were compared. Correlations between C-reactive protein (CRP) levels at diagnosis and retinochoroidal involvement were investigated. RESULTS: Compared to post-recovery follow-up examinations, patients with active MIS-C showed foveal avascular zone enlargement (p = 0.031), decreased vessel density in the temporal parafoveal SCP (p = 0.047) and all parafoveal areas of the DCP (p < 0.05 for all), and increased choroidal thickness (p = 0.021). Correlation analysis between CRP levels and OCTA changes during MIS-C revealed significant negative correlations with all parafoveal sectors of the SCP and DCP and a significant positive correlation with CT. CONCLUSION: There were especially marked effects on the DCP and choroid in MIS-C patients. Our findings also correlate with CRP levels. The use of optical coherence tomography angiography in patients with multisystemic inflammatory syndrome may have potential future implications for detecting ocular microvascular changes that occur before permanent damage develops. Clinical Trial Registration Number and Date: 77/1340; March 1, 2021.
format Online
Article
Text
id pubmed-9421118
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-94211182022-08-30 Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children Kurumoğlu Incekalan, Tuğba Celik, Umit Tolunay, Orkun Naz Şimdivar, Goksu Hande Alyamaç Sukgen, Emine Int Ophthalmol Original Paper PURPOSE: To evaluate patients with multisystemic inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using optical coherence tomography angiography (OCTA) during and after resolution of inflammation to investigate the effect of this entity on the retinal and choroidal circulation. METHODS: The study included 38 eyes of 19 patients diagnosed as having MIS-C between March 2021 and June 2021. OCTA measurements of choroidal thickness and vessel density in the radial peripapillary capillary plexus (RPCP), superficial capillary plexus (SCP), and deep capillary plexus (DCP) obtained at time of diagnosis and 60 days later were compared. Correlations between C-reactive protein (CRP) levels at diagnosis and retinochoroidal involvement were investigated. RESULTS: Compared to post-recovery follow-up examinations, patients with active MIS-C showed foveal avascular zone enlargement (p = 0.031), decreased vessel density in the temporal parafoveal SCP (p = 0.047) and all parafoveal areas of the DCP (p < 0.05 for all), and increased choroidal thickness (p = 0.021). Correlation analysis between CRP levels and OCTA changes during MIS-C revealed significant negative correlations with all parafoveal sectors of the SCP and DCP and a significant positive correlation with CT. CONCLUSION: There were especially marked effects on the DCP and choroid in MIS-C patients. Our findings also correlate with CRP levels. The use of optical coherence tomography angiography in patients with multisystemic inflammatory syndrome may have potential future implications for detecting ocular microvascular changes that occur before permanent damage develops. Clinical Trial Registration Number and Date: 77/1340; March 1, 2021. Springer Netherlands 2022-08-29 2023 /pmc/articles/PMC9421118/ /pubmed/36036326 http://dx.doi.org/10.1007/s10792-022-02382-7 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Kurumoğlu Incekalan, Tuğba
Celik, Umit
Tolunay, Orkun
Naz Şimdivar, Goksu Hande
Alyamaç Sukgen, Emine
Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title_full Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title_fullStr Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title_full_unstemmed Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title_short Changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
title_sort changes in retinal and choroidal capillary dynamics in patients with multisystem inflammatory syndrome in children
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421118/
https://www.ncbi.nlm.nih.gov/pubmed/36036326
http://dx.doi.org/10.1007/s10792-022-02382-7
work_keys_str_mv AT kurumogluincekalantugba changesinretinalandchoroidalcapillarydynamicsinpatientswithmultisysteminflammatorysyndromeinchildren
AT celikumit changesinretinalandchoroidalcapillarydynamicsinpatientswithmultisysteminflammatorysyndromeinchildren
AT tolunayorkun changesinretinalandchoroidalcapillarydynamicsinpatientswithmultisysteminflammatorysyndromeinchildren
AT nazsimdivargoksuhande changesinretinalandchoroidalcapillarydynamicsinpatientswithmultisysteminflammatorysyndromeinchildren
AT alyamacsukgenemine changesinretinalandchoroidalcapillarydynamicsinpatientswithmultisysteminflammatorysyndromeinchildren