Double-stranded RNA reduction by chaotropic agents during in vitro transcription of messenger RNA

In-vitro-transcribed messenger RNA (mRNA) has recently shown increasing significance in the development of vaccines and therapeutics. Immunogenic double-stranded RNA (dsRNA) is an undesired byproduct formed during in vitro transcription (IVT), and it is challenging to reduce dsRNA byproduct from mRN...

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Detalles Bibliográficos
Autores principales: Piao, Xijun, Yadav, Vibha, Wang, Eddie, Chang, Wayne, Tau, Lanna, Lindenmuth, Benjamin E., Wang, Sharon X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421179/
https://www.ncbi.nlm.nih.gov/pubmed/36090758
http://dx.doi.org/10.1016/j.omtn.2022.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421179/
https://www.ncbi.nlm.nih.gov/pubmed/36090758
http://dx.doi.org/10.1016/j.omtn.2022.08.001

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