Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer

BACKGROUND AND AIMS: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive DNA sequences t...

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Detalles Bibliográficos
Autores principales: Tosti, Elena, Almeida, Ana S., Tran, Tam T.T., Barbachan e Silva, Mariel, Broin, Pilib Ó., Dubin, Robert, Chen, Ken, Beck, Amanda P., Mclellan, Andrew S., Vilar, Eduardo, Golden, Aaron, O’Toole, Paul W., Edelmann, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421583/
https://www.ncbi.nlm.nih.gov/pubmed/35688320
http://dx.doi.org/10.1016/j.jcmgh.2022.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421583/
https://www.ncbi.nlm.nih.gov/pubmed/35688320
http://dx.doi.org/10.1016/j.jcmgh.2022.05.010

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