Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents

[Image: see text] Aberrant regulation of N(6)-methyladenosine (m(6)A) RNA modification has been implicated in the progression of multiple diseases, including cancer. Previously, we identified a small molecule inhibitor of the m(6)A demethylase fat mass- and obesity-associated protein (FTO), which re...

Descripción completa

Detalles Bibliográficos
Autores principales: Huff, Sarah, Kummetha, Indrasena Reddy, Zhang, Lingzhi, Wang, Lingling, Bray, William, Yin, Jiekai, Kelley, Vanessa, Wang, Yinsheng, Rana, Tariq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421652/
https://www.ncbi.nlm.nih.gov/pubmed/35939803
http://dx.doi.org/10.1021/acs.jmedchem.1c02075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421652/
https://www.ncbi.nlm.nih.gov/pubmed/35939803
http://dx.doi.org/10.1021/acs.jmedchem.1c02075

Ejemplares similares