Activation of pancreatic stellate cells attenuates intracellular Ca(2+) signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites

Alcohol abuse, an increasing problem in developed societies, is one of the leading causes of acute and chronic pancreatitis. Alcoholic pancreatitis is often associated with fibrosis mediated by activated pancreatic stellate cells (PSCs). Alcohol toxicity predominantly depends on its non-oxidative me...

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Detalles Bibliográficos
Autores principales: Kusiak, Agnieszka A., Jakubowska, Monika A., Stopa, Kinga B., Zhang, Xiaoying, Huang, Wei, Gerasimenko, Julia V., Gerasimenko, Oleg V., Sutton, Robert, Petersen, Ole H., Ferdek, Pawel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421659/
https://www.ncbi.nlm.nih.gov/pubmed/36038551
http://dx.doi.org/10.1038/s41419-022-05186-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421659/
https://www.ncbi.nlm.nih.gov/pubmed/36038551
http://dx.doi.org/10.1038/s41419-022-05186-w

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