Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells

Mantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma that remains incurable with the treatment options available today. In the present study, we have identified the dihydroorotate dehydrogenase (DHODH), an essential enzyme for the de novo biosynthesis of pyrimidine‐based nucleotides, to be overexpre...

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Detalles Bibliográficos
Autores principales: Eriksen‐Gjerstad, May, Tveit Karlsen, Ida, Fandalyuk, Zinayida, Benjaminsen, Susanne, Baran‐Marszak, Fanny, Papp, Bela, Locke, Frederick, Ladds, Marcus, Pastor‐Fernández, Andrés, Gelebart, Pascal, Mc Cormack, Emmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422018/
https://www.ncbi.nlm.nih.gov/pubmed/36051066
http://dx.doi.org/10.1002/jha2.434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422018/
https://www.ncbi.nlm.nih.gov/pubmed/36051066
http://dx.doi.org/10.1002/jha2.434

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