Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage

OBJECTIVES: The significance of antibodies directed against activated factor X (FXa) and thrombin (Thr) in patients with SLE and/or antiphospholipid syndrome (APS) is unknown. FXa and Thr are coregulated by antithrombin (AT) and activate complement. Therefore, we studied the ability of anti activate...

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Detalles Bibliográficos
Autores principales: McDonnell, Thomas, Amarnani, Raj, Spicer, Carina, Jbari, Hajar, Pericleous, Charis, Spiteri, Valentina A, Wincup, Chris, Artim-Esen, Bahar, Mackie, Ian, Botto, Marina, Rahman, Anisur, Giles, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422842/
https://www.ncbi.nlm.nih.gov/pubmed/36007979
http://dx.doi.org/10.1136/lupus-2022-000738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422842/
https://www.ncbi.nlm.nih.gov/pubmed/36007979
http://dx.doi.org/10.1136/lupus-2022-000738

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