Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis

BACKGROUND AND OBJECTIVES: In a phase 1 amyotrophic lateral sclerosis (ALS) study, autologous infusions of expanded regulatory T-lymphocytes (Tregs) combined with subcutaneous interleukin (IL)-2 were safe and well tolerated. Treg suppressive function increased and disease progression stabilized duri...

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Detalles Bibliográficos
Autores principales: Thonhoff, Jason R., Berry, James D., Macklin, Eric A., Beers, David R., Mendoza, Patricia A., Zhao, Weihua, Thome, Aaron D., Triolo, Fabio, Moon, James J., Paganoni, Sabrina, Cudkowicz, Merit, Appel, Stanley H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423710/
https://www.ncbi.nlm.nih.gov/pubmed/36038262
http://dx.doi.org/10.1212/NXI.0000000000200019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423710/
https://www.ncbi.nlm.nih.gov/pubmed/36038262
http://dx.doi.org/10.1212/NXI.0000000000200019

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