Cargando…
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Antidepressants have been reported to enhance stroke recovery independent of the presence of depressive symptoms. They have recently been proposed to exert their mood-stabilizing actions by inhibition of acid sphingomyelinase (ASM), which catalyzes the hydrolysis of sphingomyelin to ceramide. Their...
Autores principales: | Mohamud Yusuf, Ayan, Hagemann, Nina, Zhang, Xiaoni, Zafar, Maria, Hussner, Tanja, Bromkamp, Carolin, Martiny, Carlotta, Tertel, Tobias, Börger, Verena, Schumacher, Fabian, Solari, Fiorella A., Hasenberg, Mike, Kleinschnitz, Christoph, Doeppner, Thorsten R., Kleuser, Burkhard, Sickmann, Albert, Gunzer, Matthias, Giebel, Bernd, Kolesnick, Richard, Gulbins, Erich, Hermann, Dirk M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424180/ https://www.ncbi.nlm.nih.gov/pubmed/36038749 http://dx.doi.org/10.1007/s00395-022-00950-7 |
Ejemplares similares
-
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
por: Hagemann, Nina, et al.
Publicado: (2020) -
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice
por: Gregorius, Jonas, et al.
Publicado: (2021) -
Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
por: Wang, Chen, et al.
Publicado: (2021) -
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
por: Meiners, Jana, et al.
Publicado: (2019) -
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
por: Yin, Dongpei, et al.
Publicado: (2023)